Aromatic Ketone-Catalyzed Photochemical Synthesis of Imidazo-isoquinolinone Derivatives
Bin Zhao, Gerald B. Hammond, Bo Xu
Abstract
We have developed an efficient photocatalytic decarboxylative radical addition/cyclization strategy to synthesize imidazo-isoquinolinone derivatives using inexpensive aromatic ketone photocatalysts. This method not only tolerates a wide range of functional groups but also works well for both alkyl and aryl radicals.
Topics & Concepts
ChemistryKetoneCatalysisArylRadicalPhotocatalysisAlkylPhotoredox catalysisOrganic chemistryCombinatorial chemistryRadical Photochemical ReactionsCatalytic C–H Functionalization MethodsOxidative Organic Chemistry Reactions