The influence of different carbonate ligands on the hydrolytic stability and reduction of platinum(<scp>iv</scp>) prodrugs
Shu Chen, Ka-Yan Ng, Qiyuan Zhou, Houzong Yao, Zhiqin Deng, Man‐Kit Tse, Guangyu Zhu
Abstract
on the carbonyl carbon, followed by elimination, which is different from that of Pt(IV) carboxylates. This study provides some information on the influence of axial carbonate ligands with different electron-withdrawing abilities on the properties of the Pt(IV) center, which may inspire new thoughts on the design of "multi-action" Pt(IV) prodrugs.
Topics & Concepts
ChemistryProdrugHydrolysisCarbonateCatalysisCarboxylateCombinatorial chemistryMedicinal chemistryStereochemistryOrganic chemistryBiochemistryMetal complexes synthesis and propertiesFerrocene Chemistry and ApplicationsOrganometallic Complex Synthesis and Catalysis