Tailoring biocompatibility of composite scaffolds of collagen/guar gum with metal–organic frameworks
Martín Caldera‐Villalobos, Denis A. Cabrera‐Munguía, Juan J. Becerra‐Rodríguez, Jesús A. Claudio‐Rizo
Abstract
reaching up to 84 ± 5% of inhibition compared with amoxicillin (20 ppm). Further, the immunological assays revealed that the composites produce a favorable cell signaling stimulating the secretion of the TGF-β and MCP-1 cytokines and maintaining the secretion of TNF-α in normal levels. Finally, the composites showed potential to be used as controlled drug delivery systems reaching a release efficiency of 30.5 ± 2.5% for ketorolac. Finally, results revealed that ColGG-Zn(Atz)(Py) was the best formulation evaluated.
Topics & Concepts
BiocompatibilitySelf-healing hydrogelsGuar gumComposite numberMicroporous materialDrug deliveryChemistryPapainMaterials scienceMetal-organic frameworkChemical engineeringBiomedical engineeringNanotechnologyPolymer chemistryComposite materialBiochemistryAdsorptionOrganic chemistryEnzymeEngineeringMedicineElectrospun Nanofibers in Biomedical ApplicationsWound Healing and TreatmentsPeriodontal Regeneration and Treatments