Rare genetic variability in human drug target genes modulates drug response and can guide precision medicine
Yitian Zhou, Gabriel Herras Arribas, Ainoleena Turku, Tuuli Jürgenson, Souren Mkrtchian, Kristi Krebs, Yì Wáng, Barbora Svobodová, Lili Milani, Gunnar Schulte, Jan Korábečný, Stefano Gastaldello, Volker M. Lauschke
Abstract
variant confers resistance to tacrine and rivastigmine, which can be overcome by the use of derivatives based on squaric acid scaffolds or tryptophan conjugation. These findings underscore the importance of genetic drug target variability and demonstrate that integration of genomic data and structural information can inform personalized drug selection and genetically guided drug development to overcome resistance.
Topics & Concepts
DrugComputational biologyDrug targetDrug resistanceDrug developmentPrecision medicinePharmacogenomicsDrug discoveryGeneBiologyPersonalized medicinePharmacologyGeneticsMedicineBioinformaticsComputational Drug Discovery MethodsMicrobial Natural Products and BiosynthesisPharmacogenetics and Drug Metabolism