Regulatory T cells promote innate inflammation after skin barrier breach via TGF-β activation
J. Moreau, Miqdad O. Dhariwala, Victoire Gouirand, Devi P Boda, Ian C. Boothby, Margaret M. Lowe, Jarish N. Cohen, Courtney E. Macon, John Leech, Lokesh A. Kalekar, Tiffany C. Scharschmidt, Michael D. Rosenblum
Abstract
in the skin, somewhat paradoxical to their canonical immunosuppressive functions, facilitated inflammation acutely after loss of barrier integrity to promote host defense against infection.
Topics & Concepts
InflammationImmunologyBiologyCell biologyHair follicleInnate lymphoid cellAutoimmunityRegeneration (biology)Innate immune systemImmune systemT-cell and B-cell ImmunologyImmune Response and InflammationImmune Cell Function and Interaction