Manganese-induced alpha-synuclein overexpression aggravates mitochondrial damage by repressing PINK1/Parkin-mediated mitophagy
Zhiqi Liu, Kuan Liu, Zhuofan Liu, Lin Cong, Meng‐Yu Lei, Zhuo Ma, Jing Li, Yu Deng, Wei Liu, Bin Xu
Topics & Concepts
ParkinMitophagyPINK1MitochondrionGene knockdownNeurotoxicityCell biologyAlpha-synucleinDownregulation and upregulationMolecular biologyChemistrySmall hairpin RNABiologyAutophagyParkinson's diseaseMedicineApoptosisBiochemistryInternal medicineToxicityGeneDiseaseOrganic chemistryParkinson's Disease Mechanisms and TreatmentsAlzheimer's disease research and treatmentsAutophagy in Disease and Therapy