Intermolecular proton transfer from flavonol to human serum albumin triggers a red-shifted ratiometric fluorescence response
Zhongyong Xu, Mingyuan Zhang, Zihao Chen, Yutian Zhao, Lei Wang, Xiaoqiang Chen, Bin Liu, Xiaojun Peng
Abstract
Intermolecular proton transfer from a flavonol-based probe to the arginine (Arg222) in drug site 1 of human serum albumin triggers an unusual red-shifted ratiometric fluorescence response, which can be applied in the point-to-care diagnosis of hypoalbuminemia.
Topics & Concepts
FluorescenceChemistryIntermolecular forceHuman serum albuminPhotochemistryProtonAlbuminBiophysicsSerum albuminChromatographyBiochemistryOrganic chemistryMoleculeBiologyPhysicsQuantum mechanicsProtein Interaction Studies and Fluorescence AnalysisLanthanide and Transition Metal ComplexesElectron Spin Resonance Studies