Synonymous Mutations Can Alter Protein Dimerization Through Localized Interface Misfolding Involving Self-entanglements
Pham Dang Lan, Daniel A. Nissley, Ian Sitarik, Quyen V. Vu, Yang Jiang, Philip To, Yingzi Xia, Stephen D. Fried, Mai Suan Li, Edward P. O’Brien
Topics & Concepts
DimerSilent mutationChemistryRibonucleaseProtein foldingIn silicoTranslation (biology)BiophysicsMutationMolecular dynamicsCrystallographyBiologyGeneRNAMessenger RNABiochemistryComputational chemistryMissense mutationOrganic chemistryRNA and protein synthesis mechanismsBacteriophages and microbial interactionsRNA Research and Splicing