Development of an enantioselective high-performance liquid chromatography-tandem mass spectrometry method for the quantitative determination of methorphan and its O-demethylated metabolite in human blood and its application to post-mortem samples
Alfredo Fabrizio Lo Faro, Diletta Berardinelli, Giorgia Sprega, Anastasio Tini, Jérémy Carlier, Tivadar Farkas, Francesco Paolo Busardò, Bezhan Chankvetadze
Topics & Concepts
DextrorphanChemistryChromatographyDextromethorphanSelected reaction monitoringTandem mass spectrometryMass spectrometryMetaboliteLiquid chromatography–mass spectrometryActive metaboliteLevorphanolPharmacologyBiochemistry(+)-NaloxoneOpioidMedicineReceptorRespiratory and Cough-Related ResearchPlant-based Medicinal ResearchAnalytical Chemistry and Chromatography