Jolkinolide B targets thioredoxin and glutathione systems to induce ROS-mediated paraptosis and apoptosis in bladder cancer cells
Jun Sang, Wei Li, Hongjuan Diao, Run‐Zhu Fan, Jia-Luo Huang, Lu Gan, Ming-Feng Zou, Gui‐Hua Tang, Sheng Yin
Topics & Concepts
ThioredoxinApoptosisThioredoxin reductaseMAPK/ERK pathwayReactive oxygen speciesCancer researchGlutathioneBladder cancerCancer cellProgrammed cell deathKinaseBiologyCancerOxidative stressCell biologyPharmacologyChemistryBiochemistryEnzymeGeneticsRedox biology and oxidative stressMetal complexes synthesis and propertiesGlutathione Transferases and Polymorphisms