Fe-Catalyzed Sequential C(sp<sup>3</sup>)–H/N–H Annulation of 2-Methylindoles with Ethyl Trifluoropyruvate at Room Temperature: Construction of Pyrrolo[1,2-α]indoles
Le Wang, Jia Zhou, Han-Qia Chen, Dongli Li, Jun‐Bing Lin, Ke Li, Tong‐Mei Ding, Shu‐Yu Zhang
Abstract
An efficient and benign iron-catalyzed room-temperature method was developed for direct sequential C(sp3)–H/N–H annulation to construct pyrroloindole scaffolds. This strategy features cheap and readily available raw materials and mild room-temperature reaction conditions and provides a green and practical method for the one-pot rapid synthesis of a wide range of diversely functionalized pyrrolo[1,2-α]indoles.
Topics & Concepts
AnnulationChemistryCatalysisCombinatorial chemistryReaction conditionsOrganic chemistryMedicinal chemistryCatalytic C–H Functionalization MethodsSynthesis and Catalytic ReactionsCyclopropane Reaction Mechanisms