Neutrophil Elastase Facilitates Tumor Cell Intravasation and Early Metastatic Events
Elena I. Deryugina, Alexia Carré, Veronica C. Ardi, Tomoki Muramatsu, Jonas Damgård Schmidt, Christine T. Pham, James P. Quigley
Abstract
. Together, our findings implicate NE, a potent host enzyme specific for first-responding innate immune cells, as directly involved in early metastatic events and a potential target for therapeutic intervention.
Topics & Concepts
IntravasationCancer researchMetastasisNeutrophil elastaseInnate immune systemPrimary tumorTumor microenvironmentImmune systemBiologyCancerMedicineImmunologyInflammationInternal medicineTumor cellsCell Adhesion Molecules ResearchNeutrophil, Myeloperoxidase and Oxidative MechanismsS100 Proteins and Annexins