Euglycemic diabetic ketoacidosis following major vascular surgery is a new item on the differential for postoperative acidosis
Clara M. Gomez-Sanchez, Bian Wu, Jeffrey E. Gotts, Robert W. Chang
Abstract
New pharmacologic advances in the treatment of diabetes include SGLT-2 inhibitors, which have been demonstrated in randomized-controlled clinical trials to reduce overall and cardiac-specific mortality and slow progression of chronic kidney disease. Euglycemic diabetic ketoacidosis is a rare but life-threatening complication associated with the use of SGLT-2 inhibitors. Here we describe a case of severe euglycemic diabetic ketoacidosis after lower extremity bypass in a patient taking an SGLT-2 inhibitor. Awareness of this potential complication is essential as these novel agents are increasingly used in patients with cardiovascular disease.
Topics & Concepts
MedicineDiabetic ketoacidosisComplicationDiabetes mellitusKetoacidosisAcidosisMetabolic acidosisKidney diseaseDiseaseRandomized controlled trialSurgeryType 2 diabetesClinical trialIntensive care medicineAnesthesiaInternal medicineType 1 diabetesEndocrinologyCardiovascular Function and Risk FactorsDiabetes Treatment and ManagementDiabetes and associated disorders