Lipophagy and Lipolysis Status in Lipid Storage and Lipid Metabolism Diseases
Anna Kłoska, Magdalena Węsierska, Marcelina Malinowska, Magdalena Gabig‐Cimińska, Joanna Jakóbkiewicz‐Banecka
Abstract
This review discusses how lipophagy and cytosolic lipolysis degrade cellular lipids, as well as how these pathway ys communicate, how they affect lipid metabolism and energy homeostasis in cells and how their dysfunction affects the pathogenesis of lipid storage and lipid metabolism diseases. Answers to these questions will likely uncover novel strategies for the treatment of aforementioned human diseases, but, above all, will avoid destructive effects of high concentrations of lipids-referred to as lipotoxicity-resulting in cellular dysfunction and cell death.
Topics & Concepts
LipotoxicityLipid metabolismLipolysisLipid dropletCellular metabolismLipid signalingLipidomicsMetabolismBiologyCell biologyBiochemistryEndocrinologyAdipose tissueDiabetes mellitusInsulin resistanceEnzymeLipid metabolism and biosynthesisLipid metabolism and disordersAdipose Tissue and Metabolism