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Gigantol inhibits proliferation and enhances DDP-induced apoptosis in breast-cancer cells by downregulating the PI3K/Akt/mTOR signaling pathway

Jiahui Huang, Chenxing Liu, Shuna Duan, Ji Lin, Yingyi Luo, Shengchang Tao, Shangping Xing, Xiaofeng Zhang, Haiyan Du, Huan Wang, Chunlei Huang, Gang Wei

2021Life Sciences56 citationsDOI

Topics & Concepts

PI3K/AKT/mTOR pathwayApoptosisProtein kinase BChemistryLY294002MTT assayDownregulation and upregulationCell growthCancer cellSignal transductionCancer researchBiologyCancerBiochemistryGeneticsGeneBiological and pharmacological studies of plantsPhytochemistry and Biological ActivitiesBioactive Compounds and Antitumor Agents
Gigantol inhibits proliferation and enhances DDP-induced apoptosis in breast-cancer cells by downregulating the PI3K/Akt/mTOR signaling pathway | Litcius