A Novel and Practical Continuous Flow Chemical Synthesis of Cannabidiol (CBD) and its CBDV and CBDB Analogues
Elena Chiurchiù, Susanna Sampaolesi, Pietro Allegrini, Daniele Ciceri, Roberto Ballini, Alessandro Palmieri
Abstract
Abstract Cannabidiol is one of the main non‐psychoactive cannabinoids present in Cannabis sativa and, in the last decade, it is gaining great interest among the scientific community for its pharmaceutical, nutraceutical, and cosmetic applications. Herein, we report the first continuous flow chemical synthesis of cannabidiol (CBD) and its analogues cannabidivarin (CBDV) and cannabidibutol (CBDB). This approach permits to synthesize products in very good yields (55–59 %), limiting the formation of psychoactive and illegal cannabinoids such as tetrahydrocannabinol (THC).
Topics & Concepts
CannabidiolChemistryLimitingCannabis sativaTetrahydrocannabinolCannabisCannabinoidNanotechnologyCombinatorial chemistryBiochemistryBotanyPsychiatryEngineeringMechanical engineeringReceptorBiologyPsychologyMaterials scienceCannabis and Cannabinoid ResearchPharmacological Receptor Mechanisms and EffectsPancreatic function and diabetes