Relationship of brain edema after deep brain stimulation surgery with motor and cognitive function
Yamato Nishiguchi, Keita Matsuura, Yoshinori Hirata, Akane Mizutani, Natsuko Kato, Hidehiro Ishikawa, Koichi Miyashita, Takaya Utsunomiya, Hiroyuki Kajikawa, Hirofumi Nishikawa, Tomohiro Araki, Akihiro Shindo, Hidekazu Tomimoto
Abstract
Background: Some patients with Parkinson's disease (PD) develop peri-lead brain edema after deep brain stimulation (DBS) surgery. The influence of edema on neurological function is not well characterized. We investigated the relationship of brain edema after DBS surgery with motor and cognitive function. Methods: Thirteen patients with PD (6 males and 7 females; mean age: 61.2 years) who underwent bilateral subthalamic nucleus (STN) DBS surgery were included. All patients underwent magnetic resonance imaging (MRI) examination on day 6 post-DBS surgery. The volume of edema was measured either in the frontal white matter or STN on fluid attenuated inversion recovery (FLAIR) images. We examined the relationship between these volumes and changes in cognitive and motor function. Results: (SE-group; n = 10) showed that frequency of DBS tuning in the early postoperative period of the SE + group was lesser than that in the SE-group. Conclusions: Development of FE after DBS surgery was related to transient cognitive decline. On the other hand, SE seemed associated with altered motor function and reduces the requirement for tuning in the initial period after DBS implantation.