Sirt6 protects cardiomyocytes against doxorubicin-induced cardiotoxicity by inhibiting P53/Fas-dependent cell death and augmenting endogenous antioxidant defense mechanisms
Sisi Wu, Jie Lan, Lingyu Li, Xiaoxiao Wang, Mingming Tong, Fu Li, Yanjing Zhang, Jiayi Xu, Xuemei Chen, Hong‐Ying Chen, Ruli Li, Wu Yao, Juan-Juan Xin, Xin Yan, He Li, Kunyue Xue, Xue Li, Caili Zhuo, Wei Jiang
Topics & Concepts
Oxidative stressSirtuinCardiotoxicityProgrammed cell deathApoptosisSIRT6Fas ligandHistone deacetylaseCell biologyBiologyCancer researchChemistryPharmacologyNAD+ kinaseHistoneBiochemistryToxicityOrganic chemistryEnzymeGeneSirtuins and Resveratrol in MedicineChemotherapy-induced cardiotoxicity and mitigationPARP inhibition in cancer therapy