Nanomedicine for combination of chemodynamic therapy and immunotherapy of cancers
Waqas Ahmad, Wasim Sajjad, Qinghao Zhou, Zhishen Ge
Abstract
and the lack of catalytic metal ions usually limit the final therapeutic effect. The combination of CDT with immunotherapy will be an effective means to improve the therapeutic effect. In this review paper, the recent progress related to nanomedicine for the combination of CDT and immunotherapy is summarized. Immunogenic death of tumor cells, immune checkpoint inhibitors, and stimulator of interferon gene (STING) activation as the main immunotherapy strategies to combine with CDT are discussed. Finally, the challenges and prospects for the clinical translation and future development direction are discussed.
Topics & Concepts
ImmunotherapyNanomedicineMedicineCancer researchCombination therapyImmunologyPharmacologyImmune systemNanotechnologyMaterials scienceNanoparticleNanoplatforms for cancer theranosticsNanoparticle-Based Drug DeliveryImmunotherapy and Immune Responses