Transforming growth factor beta type 1 (TGF-β) and hypoxia-inducible factor 1 (HIF-1) transcription complex as master regulators of the immunosuppressive protein galectin-9 expression in human cancer and embryonic cells
Anette Teo Hansen Selnø, Stephanie Schlichtner, Inna M. Yasinska, Svetlana Sakhnevych, Walter Fiedler, Jasmin Wellbrock, Elena Klenova, Ludmila Pavlova, Bernhard F. Gibbs, Martin Degen, Isabelle Schnyder, Nijas Aliu, Steffen Berger, Elizaveta Fasler‐Kan, Vadim V. Sumbayev
Abstract
non-malignant cells. This study uncovered a self-supporting biochemical mechanism underlying high levels of galectin-9 expression operated by the human cancer and embryonic cells employed in our investigations. Our results suggest the possibility of using the TGF-β1 signalling pathway as a potential highly efficient target for cancer immunotherapy.
Topics & Concepts
Transcription factorTransforming growth factorTransforming growth factor, beta 3Cancer researchTransforming growth factor betaCell biologyHypoxia-Inducible Factor 1Cancer cellBiologyChemistryGrowth factorCancerGeneTGF alphaGeneticsReceptorGalectins and Cancer BiologyRNA modifications and cancerFOXO transcription factor regulation