3-Arylamino-quinoxaline-2-carboxamides inhibit the PI3K/Akt/mTOR signaling pathways to activate P53 and induce apoptosis
Nan‐Ying Chen, Ke Lu, Jing‐Mei Yuan, Xiaojuan Li, Zi-Yu Gu, Cheng‐Xue Pan, Dong‐Liang Mo, Gui‐Fa Su
Topics & Concepts
PI3K/AKT/mTOR pathwayProtein kinase BChemistryRPTORApoptosisPhosphorylationQuinoxalineSignal transductionKinaseCell biologyCell growthCancer researchBiochemistryBiologyOrganic chemistrySynthesis and Biological EvaluationQuinazolinone synthesis and applicationsSynthesis and biological activity