L-type Ca <sup>2+</sup> channel–mediated Ca <sup>2+</sup> influx adjusts neuronal mitochondrial function to physiological and pathophysiological conditions
Matej Hoťka, Michal Cagalinec, Karlheinz Hilber, Livia C. Hool, Stefan Boehm, Helmut Kubista
Abstract
influx in the tuning and maintenance of mitochondrial function. Therefore, the use of LTCC inhibitors to protect neurons from neurodegeneration should be reconsidered carefully.
Topics & Concepts
MitochondrionCell biologyExtracellularBiophysicsUniporterBicucullineChemistryBiologyNeuroscienceBiochemistryGABAA receptorCytosolReceptorEnzymeNeuroscience and Neuropharmacology ResearchIon channel regulation and functionCardiac Ischemia and Reperfusion