miR-375 prevents high-fat diet-induced insulin resistance and obesity by targeting the aryl hydrocarbon receptor and bacterial tryptophanase (<i>tnaA</i>) gene
Anil Kumar, Yi Ren, Kumaran Sundaram, Jingyao Mu, Mukesh K. Sriwastva, Gerald W. Dryden, Chao Lei, Lifeng Zhang, Jun Yan, Xiang Zhang, Juw Won Park, Michael L. Merchant, Yun Teng, Huang‐Ge Zhang
Abstract
Collectively our findings reveal that oral administration of GDNP to HFD mice improves host glucose tolerance and insulin response via regulating AhR expression by GDNP induced miR-375 and VAMP7.
Topics & Concepts
Insulin resistanceObesityAryl hydrocarbon receptorDiabetes mellitusInternal medicineInsulinEndocrinologyMedicineChemistryGenePharmacologyBiochemistryTranscription factorGinger and Zingiberaceae researchTryptophan and brain disordersImmune cells in cancer