Allicin suppressed <i>Escherichia coli</i>-induced urinary tract infections by a novel MALT1/NF-κB pathway
Zhenglin Chang, Lingyue An, Zhican He, Yuyan Zhang, Shujue Li, Min Lei, Peng Xu, Yongchang Lai, Zheng Jiang, Yapeng Huang, Xiaolu Duan, Wenqi Wu
Abstract
Our experiments revealed that the therapeutic effects of allicin against E . coli induced urinary inflammation were characterized by the restoration of the highly expressed MALT1, the activated AKT/NF-κB pathway, and excessive release of cytokines.
Topics & Concepts
AllicinProtein kinase BEscherichia coliBiologyPI3K/AKT/mTOR pathwayNF-κBMicrobiologyPharmacologySignal transductionChemistryBiochemistryGeneGarlic and Onion StudiesNephrotoxicity and Medicinal PlantsUrinary Tract Infections Management