The 4D Nucleome Data Portal as a resource for searching and visualizing curated nucleomics data
Sarah B. Reiff, Andrew J. Schroeder, Koray Kırlı, Andrea Cosolo, Clara Bakker, Luisa Mercado, Soohyun Lee, Alexander Veit, Alexander Balashov, Carl Vitzthum, William Ronchetti, Kent M. Pitman, Jeremy Johnson, Shannon Ehmsen, Peter Kerpedjiev, Nezar Abdennur, Maxim Imakaev, Serkan Utku Öztürk, Uğur Çamoğlu, Leonid A. Mirny, Nils Gehlenborg, B. Alver, Peter J. Park
Abstract
The 4D Nucleome (4DN) Network aims to elucidate the complex structure and organization of chromosomes in the nucleus and the impact of their disruption in disease biology. We present the 4DN Data Portal ( https://data.4dnucleome.org/ ), a repository for datasets generated in the 4DN network and relevant external datasets. Datasets were generated with a wide range of experiments, including chromosome conformation capture assays such as Hi-C and other innovative sequencing and microscopy-based assays probing chromosome architecture. All together, the 4DN data portal hosts more than 1800 experiment sets and 36000 files. Results of sequencing-based assays from different laboratories are uniformly processed and quality-controlled. The portal interface allows easy browsing, filtering, and bulk downloads, and the integrated HiGlass genome browser allows interactive visualization and comparison of multiple datasets. The 4DN data portal represents a primary resource for chromosome contact and other nuclear architecture data for the scientific community.