Endogenous tryptophan metabolite 5-Methoxytryptophan inhibits pulmonary fibrosis by downregulating the TGF-β/SMAD3 and PI3K/AKT signaling pathway
Le Fang, Hongtao Chen, Renyi Kong, Jun Que
Topics & Concepts
Pulmonary fibrosisIdiopathic pulmonary fibrosisMyofibroblastBleomycinCancer researchFibrosisPI3K/AKT/mTOR pathwayProtein kinase BExtracellular matrixChemistrySignal transductionLungMedicinePathologyInternal medicineBiochemistryChemotherapyInterstitial Lung Diseases and Idiopathic Pulmonary FibrosisOccupational and environmental lung diseasesEosinophilic Disorders and Syndromes