Top-down synthetic biology approach for titer improvement of clinically important antibiotic daptomycin in Streptomyces roseosporus
Chang-Hun Ji, Hiyoung Kim, Hyun-Woo Je, Haeun Kwon, Dongho Lee, Hahk‐Soo Kang
Topics & Concepts
DaptomycinLipopeptideBiologySynthetic biologyTiterGeneMetabolic engineeringStreptomycesComputational biologyIn silicoGeneticsBacteriaAntibodyVancomycinStaphylococcus aureusMicrobial Natural Products and BiosynthesisRNA and protein synthesis mechanismsMicrobial Metabolism and Applications