Variation in the hemoglobin glycation index
James M. Hempe, Daniel S. Hsia
Abstract
A high hemoglobin glycation index (HGI) has been repeatedly associated with greater risk for hypoglycemia in people with diabetes and greater risk for chronic vascular disease in people with or without diabetes. This review explores how different sources of analytical and biological variation in HbA1c and blood glucose individually and collectively affect the clinical information value of HGI. We conclude that HGI is a complex quantitative trait that is a clinically practical biomarker of risk for both hypoglycemia and chronic vascular disease.
Topics & Concepts
MedicineDiabetes mellitusGlycationHypoglycemiaHemoglobinBiomarkerInternal medicineGlycated hemoglobinGlycemic indexHemoglobin ADiseaseType 2 diabetesEndocrinologyGlycemicBiochemistryChemistryDiabetes, Cardiovascular Risks, and LipoproteinsDiabetes Management and ResearchAdvanced Glycation End Products research