Males with sickle cell disease have higher risks of cerebrovascular disease, increased inflammation, and a reduced response to hydroxyurea
Margherita Di Mauro, Sara El Hoss, Amina Nardo‐Marino, Sara Stuart‐Smith, John Strouboulis, John S. Gibson, David C. Rees, John Brewin
Abstract
Biological sex is important. Male sex is associated with worse outcomes in most measures, including cerebrovascular disease, hospital admissions, and blood transfusions, but not survival. Females also appear to have a better response to hydroxyurea therapy, reduced markers of inflammation, and better liver function.
Topics & Concepts
MedicineDiseaseCohortInternal medicineClinical trialCohort studyBioinformaticsOncologyImmunologyBiologyHemoglobinopathies and Related DisordersIron Metabolism and DisordersPrenatal Screening and Diagnostics