Glucosamine enhances proliferation, barrier, and anti-oxidative functions in porcine trophectoderm cells
Beibei He, Jun Bai, Zhenlong Wu
Abstract
GlcN increased the protein expression of zonula occludens-3 (ZO-3), claudin-3, and claudin-4 in pTr cells, while inhibited the downregulation protein of claudin-1 and claudin-3 brought about by oxidative stress. Collectively, GlcN plays an important role in promoting proliferation and stimulating the mTOR cell signaling pathway, as well as ameliorating oxidative stress and augmenting barrier functions in pTr cells.
Topics & Concepts
Paracellular transportCell biologyCell growthViability assayBiologyGlutaminePI3K/AKT/mTOR pathwayReactive oxygen speciesOccludinBiochemistryMolecular biologyChemistryCellSignal transductionTight junctionPermeability (electromagnetism)MembraneAmino acidReproductive Biology and FertilityLiver physiology and pathologyPancreatic function and diabetes