Collagen type VI is the antigen recognized by the ER‐TR7 antibody
Alvise Schiavinato, Matthias Przyklenk, Birgit Kobbe, Mats Paulsson, Raimund Wagener
Abstract
The monoclonal antibody ER-TR7 was used in a great number of studies for detecting reticular fibroblasts and the ECM of lymphoid and non-lymphoid organs even if the protein recognized by the ER-TR7 antibody was not known. We have now identified native collagen VI microfibrils as its tissue antigen.
Topics & Concepts
BiologyAntigenAntibodyReticular connective tissueMonoclonal antibodyLymphatic systemImmunologyMolecular biologyAnatomyCell Adhesion Molecules ResearchCardiac Fibrosis and RemodelingElasticity and Material Modeling