Inhibitory Compounds Targeting Plasmodium falciparum Gyrase B
Zuzanna Pakosz, Ting‐Yu Lin, Elizabeth Michalczyk, S. Nagano, Jonathan G. Heddle
Abstract
Malaria persists as a major health problem due to the spread of drug resistance and the lack of effective vaccines. DNA gyrase is a well-validated and extremely effective therapeutic target in bacteria, and it is also known to be present in the apicoplast of malarial species, including Plasmodium falciparum . This raises the possibility that it could be a useful target for novel antimalarials.
Topics & Concepts
Plasmodium falciparumDNA gyraseApicoplastMalariaDrug resistanceBiologyVirologyPlasmodium (life cycle)PharmacologyMicrobiologyApicomplexaGeneticsImmunologyGeneEscherichia coliParasite hostingWorld Wide WebComputer scienceMalaria Research and ControlHIV/AIDS drug development and treatmentResearch on Leishmaniasis Studies