CaO<sub>2</sub>/gelatin oxygen slow-releasing microspheres facilitate tissue engineering efficiency for the osteonecrosis of femoral head by enhancing the angiogenesis and survival of grafted bone marrow mesenchymal stem cells
Chengqiang Wang, Haixia Xu, Chun Liu, Ziyue Peng, Ruoxing Min, Zhiming Zhang, Jianjun Li, Yanglei Jin, Yihan Wang, Zhihao Li, Jiasong Guo, Lixin Zhu
Abstract
). The in vivo study demonstrated that the transplanted scaffold with oxygen-generating microspheres significantly enhanced the osteogenic and angiogenic effects compared to the scaffold without microspheres. Further assessments revealed that microspheres in the scaffold can reduce the local cell apoptosis and enhance the survival of grafted cells in the host. Collectively, the present study developed a novel oxygen slow-releasing composite scaffold, which can facilitate tissue engineering efficiency for treating the osteonecrosis of the femoral head by enhancing the angiogenesis and survival of grafted stem cells.