Zwitterionic choline phosphate conjugated folate-poly (ethylene glycol): a general decoration of erythrocyte membrane-coated nanoparticles for enhanced tumor-targeting drug delivery
Yuyue Zhang, Yuemin Wang, Qiangwei Xin, Mingjing Li, Peng Yu, Jun Luo, Xinyuan Xu, Xingyu Chen, Jianshu Li
Abstract
-glycolic acid) (PLGA) nanosystem to form a tumor-targeting erythrocyte membrane nanosystem (FA-RBC@PLGA-DOX). The results show that MCP-PEG-FA was synthesized and successfully bonded to the erythrocyte membrane nanosystem, and the FA-RBC@PLGA-DOX nanosystem had a better tumor-targeting function and tumor killing effect compared with those of the nanosystems without FA ligand modification. The universal modification method of erythrocyte membranes is successfully provided and can be applied to the treatment of various diseases.
Topics & Concepts
Ethylene glycolConjugated systemDrug deliveryNanoparticleMembraneDrugCholineDrug carrierPhosphateMaterials scienceChemistryNuclear chemistryPolymer chemistryOrganic chemistryNanotechnologyBiochemistryPharmacologyPolymerMedicineNanoparticle-Based Drug DeliveryPhagocytosis and Immune RegulationRNA Interference and Gene Delivery