LncRNA-SLC16A1-AS1 induces metabolic reprogramming during Bladder Cancer progression as target and co-activator of E2F1
Stella Logotheti, Stephan Marquardt, Shailendra K. Gupta, Christin Richter, Berdien A. H. Edelhäuser, David Engelmann, Julia Brenmoehl, Christoph Söhnchen, Nico Murr, Michael P. Alpers, Krishna P. Singh, Olaf Wolkenhauer, Dirk Heckl, Alf Spitschak, Brigitte M. Pützer
Abstract
Our results unveil a new gene regulatory program by which E2F1-induced lncRNA-SLC16A1-AS1 forms a complex with its transcription factor that promotes cancer metabolic reprogramming towards the acquisition of a hybrid oxidative phosphorylation/glycolysis cell phenotype favoring BC invasiveness.
Topics & Concepts
ReprogrammingCancer researchCancerBladder cancerActivator (genetics)BiologyChemistryCell biologyInternal medicineMedicineBiochemistryReceptorGeneCancer-related molecular mechanisms researchRNA modifications and cancerEpigenetics and DNA Methylation