Spinal microglia-derived TNF promotes the astrocytic JNK/CXCL1 pathway activation in a mouse model of burn pain
Run Zhang, Biao Xu, Nan Zhang, Jiandong Niu, Mengna Zhang, Qinqin Zhang, Dan Chen, Yonghang Shi, Danni Chen, Kedi Liu, Xiaodi Zhang, Ning Li, Quan Fang
Topics & Concepts
MicrogliaCXCL1MedicineAstrocyteMAPK/ERK pathwayDownregulation and upregulationChemokineAllodyniaTumor necrosis factor alphap38 mitogen-activated protein kinasesPharmacologyNeuropathic painSpinal cordNeurogliaHyperalgesiaCytokineImmunologyNeuroscienceKinaseInflammationReceptorNociceptionEndocrinologyCentral nervous systemChemistryInternal medicineCell biologyBiologyGeneBiochemistryPsychiatryPain Mechanisms and TreatmentsPharmacological Effects of Natural CompoundsNeuroinflammation and Neurodegeneration Mechanisms