Betti base derived <i>P</i>-stereogenic phosphine-diamidophosphite ligands with a single atom spacer and their application in asymmetric catalysis
Soumyadeep Chakrabortty, Katharina Konieczny, Bernd Müller, Anke Spannenberg, Paul C. J. Kamer, Johannes G. de Vries
Abstract
Small bite-angle P -chirogenic PNP ligands have been synthesized stereo-selectively and employed in Rh-catalyzed asymmetric hydrogenation and Pd-catalyzed asymmetric allylic substitution resulting in moderate to excellent enantioselectivities.
Topics & Concepts
StereocenterCatalysisPhosphineChemistryAllylic rearrangementAtom (system on chip)Base (topology)Enantioselective synthesisCombinatorial chemistryStereochemistryOrganic chemistryMathematicsComputer scienceEmbedded systemMathematical analysisAsymmetric Hydrogenation and CatalysisAsymmetric Synthesis and CatalysisChemical Synthesis and Analysis