PARP inhibitor plus radiotherapy reshape the immune suppressive microenvironment and potentiate the efficacy of immune checkpoint inhibitors in tumors with IDH1 mutation
Xiaoyu Hu, Mengyu Zhao, Menglin Bai, Zhuang Xue, Fei Wang, Ziyuan Zhu, Jinming Yu, Jinbo Yue
Topics & Concepts
Cancer researchTumor microenvironmentPARP inhibitorImmunotherapyImmune checkpointSynthetic lethalityCD8T cellCCL5BiologyImmune systemPoly ADP ribose polymeraseImmunologyDNA repairIL-2 receptorGeneBiochemistryPolymeraseTumor cellsCancer Immunotherapy and BiomarkersPARP inhibition in cancer therapyImmune Cell Function and Interaction