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Why does invasive brain stimulation sometimes improve memory and sometimes impair it?

Uma R. Mohan, Joshua Jacobs

2024PLoS Biology10 citationsDOIOpen Access PDF

Abstract

Invasive brain stimulation is used to treat individuals with episodic memory loss; however, studies to date report both enhancement and impairment of memory. This Essay discusses the sources of this variability, and suggests a path towards developing customized stimulation protocols for more consistent memory enhancement.

Topics & Concepts

BiologyNeuroscienceStimulationDeep brain stimulationBrain stimulationInternal medicineDiseaseMedicineParkinson's diseaseNeurological disorders and treatmentsTranscranial Magnetic Stimulation StudiesEEG and Brain-Computer Interfaces