Alzheimer’s Disease: Understanding Motor Impairments
Jesús Andrade-Guerrero, Humberto Martínez-Orozco, Marcos M. Villegas-Rojas, Alberto Santiago-Balmaseda, Karen M. Delgado-Minjares, Isaac Pérez-Segura, Mauricio T. Baéz-Cortés, Miguel A. Del Toro-Colín, Magdalena Guerra‐Crespo, Óscar Arias-Carrión, Sofı́a Dı́az-Cintra, Luis O. Soto-Rojas
Abstract
Alzheimer's disease (AD), the most prevalent neurodegenerative disorder and the leading cause of dementia worldwide, profoundly impacts health and quality of life. While cognitive impairments-such as memory loss, attention deficits, and disorientation-predominate in AD, motor symptoms, though common, remain underexplored. These motor symptoms, including gait disturbances, reduced cardiorespiratory fitness, muscle weakness, sarcopenia, and impaired balance, are often associated with advanced stages of AD and contribute to increased mortality. Emerging evidence, however, suggests that motor symptoms may be present in earlier stages and can serve as predictive markers for AD in older adults. Despite a limited understanding of the underlying mechanisms driving these motor symptoms, several key pathways have been identified, offering avenues for further investigation. This review provides an in-depth analysis of motor symptoms in AD, discussing its progression, potential mechanisms, and therapeutic strategies. Addressing motor symptoms alongside cognitive decline may enhance patient functionality, improve quality of life, and support more comprehensive disease management strategies.