Chemoselective (Hetero)Arene Electroreduction Enabled by Rapid Alternating Polarity
Kyohei Hayashi, Jeremy Griffin, Kaid C. Harper, Yu Kawamata, Phil S. Baran
Abstract
Conventional chemical and even electrochemical Birch-type reductions suffer from a lack of chemoselectivity due to a reliance on alkali metals or harshly reducing conditions. This study reveals that a simpler avenue is available for such reductions by simply altering the waveform of current delivery, namely rapid alternating polarity (rAP). The developed method solves these issues, proceeding in a protic solvent, and can be easily scaled up without any metal additives or stringently anhydrous conditions.
Topics & Concepts
ChemistryChemoselectivityAnhydrousPolarity (international relations)Alkali metalElectrochemistryCombinatorial chemistrySolventWaveformAlternating currentInorganic chemistryOrganic chemistryCatalysisElectrodeVoltagePhysical chemistryElectrical engineeringBiochemistryCellEngineeringCO2 Reduction Techniques and CatalystsRadical Photochemical ReactionsElectrochemical Analysis and Applications