Stringent Response-Mediated Control of GTP Homeostasis Is Required for Long-Term Viability of Staphylococcus aureus
Laura Carrilero, Lucy Urwin, Ezra Ward, Naznin R. Choudhury, Ian R. Monk, Claire E. Turner, Timothy P. Stinear, Rebecca M. Corrigan
Abstract
Staphylococcus aureus is a human pathogen that upon invasion of a host encounters stresses, such as nutritional restriction. The bacteria respond by switching on a signaling cascade controlled by the nucleotides (p)ppGpp.
Topics & Concepts
Staphylococcus aureusBiologyPathogenGTP'MicrobiologyStaphylococcal infectionsBacteriaHomeostasisCell biologyGeneticsBiochemistryEnzymeAntimicrobial Resistance in StaphylococcusBacterial Genetics and BiotechnologyBacterial biofilms and quorum sensing