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Development of 1,2,3-triazole hybrids as multi-faced anticancer agents co-targeting EGFR/mTOR pathway and tubulin depolymerization

Mennatallah A. Shaheen, Khaled M. Darwish, Safaa M. Kishk, Magda A.‐A. El‐Sayed, Ismail Salama

2025Bioorganic Chemistry14 citationsDOI

Topics & Concepts

ChemistryDepolymerizationTubulinDiscovery and development of mTOR inhibitorsPI3K/AKT/mTOR pathwayTriazoleMicrotubuleCombinatorial chemistryCancer researchBiochemistryCell biologySignal transductionOrganic chemistryBiologySynthesis and biological activityClick Chemistry and ApplicationsQuinazolinone synthesis and applications
Development of 1,2,3-triazole hybrids as multi-faced anticancer agents co-targeting EGFR/mTOR pathway and tubulin depolymerization | Litcius