Recent Advances in Iodine‐Promoted C−S/N−S Bonds Formation
Honghua Zhang, Huihong Wang, Yi Jiang, Fei Cao, Weiwei Gao, Longqing Zhu, Yuhang Yang, Xiaodong Wang, Yong‐Qiang Wang, Jinhong Chen, Yiyue Feng, Xuemei Deng, Ying‐Mei Lu, Xiaoling Hu, Xiangxiang Li, Juan Zhang, Tao Shi, Zhen Wang
Abstract
Sulfur-containing scaffold, as a ubiquitous structural motif, has been frequently used in natural products, bioactive chemicals and pharmaceuticals, particularly C-S/N-S bonds are indispensable in many biological important compounds and pharmaceuticals. Development of mild and general methods for C-S/N-S bonds formation has great significance in modern research. Iodine and its derivatives have been recognized as inexpensive, environmentally benign and easy-handled catalysts or reagents to promote the construction of C-S/N-S bonds under mild reaction conditions, with good regioselectivities and broad substrate scope. Especially based on this, several new strategies, such as oxidation relay strategy, have been greatly developed and accelerated the advancement of this field. This review focuses on recent advances in iodine and its derivatives promoted hybridized C-S/N-S bonds formation. The features and mechanisms of corresponding reactions are summarized and the results of some cases are compared with those of previous reports. In addition, the future of this domain is discussed.