Direct evidence that Ataxin-2 is a translational activator mediating cytoplasmic polyadenylation
Hiroto Inagaki, Nao Hosoda, Hitomi Tsuiji, S. Hoshino
Abstract
TDP-43 proteinopathies), and this process could be a therapeutic target for Ataxin-2-related neurodegenerative disorders.
Topics & Concepts
PolyadenylationCell biologyCytoplasmBiologyChemistryGeneticsMessenger RNAGeneGenetic Neurodegenerative DiseasesUbiquitin and proteasome pathwaysAmyotrophic Lateral Sclerosis Research