Design, synthesis, and biological evaluation of dual targeting inhibitors of histone deacetylase 6/8 and bromodomain BRPF1
Ehab Ghazy, Patrik Zeyen, Daniel Herp, Martin Hügle, Karin Schmidtkunz, Frank Erdmann, Dina Robaa, Matthias Schmidt, Elizabeth R. Morales, Christophe Romier, Stefan Günther, Manfred Jung, Wolfgang Sippl
Topics & Concepts
BromodomainAcetylationChemistryHDAC6HistonePHD fingerHDAC8Docking (animal)Histone deacetylaseMyeloid leukemiaHDAC1Histone acetyltransferaseBiochemistryCancer researchCell biologyTranscription factorBiologyGeneMedicineNursingZinc fingerProtein Degradation and InhibitorsHistone Deacetylase Inhibitors ResearchPeptidase Inhibition and Analysis