Suprachoroidal Injection of Triamcinolone Acetonide Suspension: Ocular Pharmacokinetics and Distribution in Rabbits Demonstrates High and Durable Levels in the Chorioretina
Leroy Muya, Viral Kansara, Megan E. Cavet, Thomas A. Ciulla
Abstract
Suprachoroidal delivery of TA enabled high and durable TA levels targeted to the chorioretina with limited anterior segment exposure. SC delivery of either CLS-TA or TRI resulted in comparable ocular PK profiles with low systemic exposure; however, CLS-TA required lower and less variable glide force than TRI, potentiating more consistent, controlled administration.
Topics & Concepts
PharmacokineticsTriamcinolone acetonideOphthalmologyChoroidScleraMedicineOcular hypertensionCLs upper limitsCiliary bodyIntraocular pressureChemistryPharmacologyRetinaBiologyNeuroscienceRetinal Diseases and TreatmentsGlaucoma and retinal disordersIntraocular Surgery and Lenses