Effects of Metabolism on Macrophage Polarization Under Different Disease Backgrounds
Jiaxue Sun, Xianghong Xu, Liping Jin
Abstract
Macrophages are versatile immune cells associated with various diseases, and their phenotypes and functions change on the basis of the surrounding environments. Reprogramming of metabolism is required for the proper polarization of macrophages. This review will focus on basic metabolic pathways, the effects of key enzymes and specific products, relationships between cellular metabolism and macrophage polarization in different diseases and the potential prospect of therapy targeted key metabolic enzymes. In particular, the types and characteristics of macrophages at the maternal-fetal interface and their effects on a successful conception will be discussed.
Topics & Concepts
Macrophage polarizationMacrophageImmune systemReprogrammingPhenotypeMetabolismCellular metabolismCell metabolismMetabolic pathwayBiologyDiseaseCell biologyEnzymeImmunologyCellBioinformaticsComputational biologyMedicineBiochemistryIn vitroPathologyGeneImmune cells in cancerPhagocytosis and Immune RegulationNeonatal Respiratory Health Research