Transdermal Delivery of Succinate Accelerates Energy Dissipation of Brown Adipocytes to Reduce Remote Fat Accumulation
Fang‐Hsuean Liao, Chun‐Nien Yao, Shuping Chen, Te‐Haw Wu, Shu‐Yi Lin
Abstract
in BAT and other browning markers in WAT were significantly elevated in the mice that were treated with SC microneedle. Thus, the energy dissipation of BAT using UCP1-mediated thermogenesis accelerated by the transdermal delivery of SC may become a potential and effective strategy for preventing obesity.
Topics & Concepts
ThermogenesisBrown adipose tissueThermogeninWhite adipose tissueEndocrinologyInternal medicineChemistryAdipose tissueTransdermalBiologyMedicinePharmacologyAdipose Tissue and MetabolismExercise and Physiological ResponsesSirtuins and Resveratrol in Medicine