The Antibiotic Negamycin Crosses the Bacterial Cytoplasmic Membrane by Multiple Routes
Daniel Hörömpöli, Catherine Ciglia, Karl‐Heinz Glüsenkamp, Lars Ole Haustedt, Hildegard Falkenstein‐Paul, Gerd Bendas, Anne Berscheid, Heike Brötz‐Oesterhelt
Abstract
H]negamycin. The diversity of options for membrane translocation is reflected by low resistance rates. The example of negamycin demonstrates that membrane passage of antibiotics can be multifaceted and that for cytoplasmic anti-Gram-negative drugs, understanding of permeation and target interaction are equally important.
Topics & Concepts
Pseudomonas aeruginosaRibosomeStaphylococcus aureusBacteriaAntibioticsMicrobiologyEnterobacteriaceaeBiologyCytoplasmEscherichia coliGram-positive bacteriaBiochemistryRNAGeneGeneticsRNA and protein synthesis mechanismsBacterial Genetics and BiotechnologyAntibiotic Resistance in Bacteria